Quo Vadis tells of a love that develops between a young Christian woman, Ligia (or Lygia), and Marcus Vinicius, a Roman patrician. It takes place in the city of Rome under the rule of emperor Nero around AD 64.
Sienkiewicz studied the Roman Empire extensively prior to writing the novel, with the aim of getting historical details correct. As such, several historical figures appear in the book. As a whole, the novel carries a powerful pro-Christian message.